Current Bioprocessing Monitoring is Inadequate
Current bioprocess monitoring relies on indirect indicators of metabolic activity, such as glucose, pH, and dissolved oxygen. These parameters correlate with cell health but are not a direct assessment , leaving a critical blind spot in process control.
Consequently, the Bioprocessing industry relies on episodic and invasive sampling to monitor critical cell parameters. Contamination is a significant production risk caused by invasive sampling.Limited real-time data availability leads to delayed feedback and intervention . This directly contributes to bioprocessing batch failures; in fact, 7.5% of batches fail, representing greater than 30B in industry losses.
Addressing Fundamental limitations in current bioprocess monitoring through several key innovations:
Non-Invasive Monitoring Capability:
Unlike traditional methods requiring physical sampling, LarmorBio's MMR technology can monitor cell parameters without breaching the sterile barrier. This eliminates contamination risks associated with invasive sampling while enabling continuous monitoring throughout the production lifecycle.
Continuous Real-Time Monitoring:
The technology enables continuous, real-time assessment of critical cell parameters, replacing episodic sampling with constant process visibility.
Single-Use System Compatibility:
LarmorBio's technology can be integrated with single-use bioreactor systems without requiring permanent installation or complex cleaning protocols. This compatibility addresses a critical gap in the rapidly growing single-use bioprocessing market.
Publications:
Hans Gaensbauer, Do Hyun Park, Alexander Bevacqua, Jongyoon Han, “Contact Free On-Line Monitoring of Bioreactor Cell Cultures with Magnetic Resonance Relaxometry,” Analytical Chemistry,(2024) https://pubs.acs.org/doi/10.1021/acs.analchem.4c04042
Tan, J., Chen, J., Roxby, D. et al. Using magnetic resonance relaxometry to evaluate the safety and quality of induced pluripotent stem cell-derived spinal cord progenitor cells. Stem Cell Res Ther 15, 465 (2024). https://stemcellres.biomedcentral.com/articles/10.1186/s13287-024-04070-y
Tee, C.A., Roxby, D.N., Othman, R. et al. Metabolic modulation to improve MSC expansion and therapeutic potential for articular cartilage repair. Stem Cell Res Ther 15, 308 (2024). https://doi.org/10.1186/s13287-024-03923-w