Introducing A New Class of Process Analytical Tools for Biologics and Cell Therapy Production
Typical cell density and viability measurements are made by manually removing a sample from the culture, but this approach is both slow and unsuitable for small culture volumes, which cannot support frequent destructive sampling
Our approach
Automated microscale magnetic resonance measurements provide qualitative information about the culture in near real-time. The system detects variations in cell density in minutes, enabling rapid intervention that would be impossible with the once-daily measurements taken by a traditional sampling-based culture analysis
LarmorBio's micro-magnetic resonance (MMR) technology addresses fundamental limitations in current bioprocess monitoring through several key innovations:
Non-Invasive Monitoring Capability:
Unlike traditional methods requiring physical sampling, LarmorBio's MMR technology can monitor cell viability without breaching the sterile barrier. This eliminates contamination risks associated with invasive sampling while enabling continuous monitoring throughout the entire bioprocess lifecycle.
Energy-Neutral Operation:
Current monitoring technologies often introduce energy into the bioprocess through heating, electromagnetic fields, or chemical reactions. LarmorBio's MMR technology operates without addingenergy to the system, preventing disruption of sensitive cell cultures and maintaining optimal growth conditions.
Continuous Real-Time Monitoring:
The technology enables continuous, real-time assessment of cell viability, replacing episodic sampling with constant process visibility. This capability is particularly valuable for continuous bioprocessing applications where traditional batch-based monitoring approaches are inadequate.
Single-Use System Compatibility:
LarmorBio's technology can be integrated with single-use bioreactor systems without requiring permanent installation or complex cleaning protocols. This compatibility addresses a critical gap in the rapidly growing single-use bioprocessing market.
Benefits
Zero contamination risk from monitoring activities
Continuous process visibility enabling proactive intervention
Reduced operational costs through elimination invasive sampling and reagent requirements
Enhanced product quality through improved process control