Cellular oxidative stress 

platform technology  







BASIC BACKGROUND ON OXIDATIVE STRESS 

All cells, organs, and body systems (organs) share a ubiquitous homeostatic mechanism: the balance between the production of oxidative stress molecules and its continuous removal promptly. In other words, prooxidants and antioxidants usually maintain a well-balanced ratio.

For example, energy (ATP) production by the cell's powerhouse (mitochondria), via cellular respiration leads to the non-stop production of reactive oxygen species as an inevitable by-product. Nevertheless, as long as the existing antioxidants produced endogenously or received from exogenous sources are not overloaded by oxidative stress molecules, this well-balanced ratio, the state of homeostasis, will be maintained. 

Oxidative stress molecules attack macromolecules including protein, DNA and lipid etc. causing cellular and tissue damage. Consequently, a change in that balance by a continuous excess of oxidative stress (accumulation of chemically highly reactive, aggressive substances) and the induction of several pathologies in an acute setting (i.e. trauma, myocardial infarction, stroke) or a long-lasting situation (i.e. diabetes, high blood lipids, high blood pressure, excess of unhealthy food). 

The loss of the equilibrium between the production of oxidative stress and its removal (“loss of redox homeostasis”) is also characteristic of aging and degenerative processes (i.e. joints, neurons). 

Find out more about LarmorBio's unique and proven approach to quantifying oxidative stress from blood in real-time

 Molecular Phenotyping of Oxidative Stress Platform

Proprietary Microscale NMR 


 

Proprietary Data Analytics 

Recent Publications and some ongoing clinical studies

Responsive biomarker to drug interventions

GLP-1 Analogues  

Metabolic healthy vs unhealthy with varying nutritional loas

Ferroptosis: Iron-induced cellular death 

"The LarmorBio platform helped us quantify intracellular ferric Ion (Fe3+) and ferrous ion (Fe2+) homeostasis in h9c2 cardiomyoblast cells. The assay requires minimal sample preparation and is easy to use.


Truly an exciting technology that has potential diagnostic applications."


Chester Lee Drum Lab 

Duke NUS 

Monitoring blood oxidative levels in pregnant women receiving digital health intervention designed for improved metabolic health

Advanced, real-time,individualized cardiometabolic insights 

Interdisciplinary founding team

Jongyoon Han professor of biological engineering, computer science and electrical engineering at MIT, 

Inventor of LarmorBio technology

Rodolfo Rohr



CEO

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Stan Sassower



VP Engineering

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André Alves



MR Engineer

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Smitha Thamarath



Senior Scientist

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Louis Bouchard



CSO

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James Boiani



Director of Regulatory Affairs

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Bruce Volpe



Advisor
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Robert Silverman



Advisor
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Ken Andrews



Advisor
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Jongyoon Han



Inventor
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Weng Kung Peng



Inventor
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Bernhard O. Boem



Medical director 
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Work with us contact  bd@larmorbio.com