Cellular oxidative stress
platform technology
BASIC BACKGROUND ON OXIDATIVE STRESS
All cells, organs, and body systems (organs) share a ubiquitous homeostatic mechanism: the balance between the production of oxidative stress molecules and its continuous removal promptly. In other words, prooxidants and antioxidants usually maintain a well-balanced ratio.
For example, energy (ATP) production by the cell's powerhouse (mitochondria), via cellular respiration leads to the non-stop production of reactive oxygen species as an inevitable by-product. Nevertheless, as long as the existing antioxidants produced endogenously or received from exogenous sources are not overloaded by oxidative stress molecules, this well-balanced ratio, the state of homeostasis, will be maintained.
Oxidative stress molecules attack macromolecules including protein, DNA and lipid etc. causing cellular and tissue damage. Consequently, a change in that balance by a continuous excess of oxidative stress (accumulation of chemically highly reactive, aggressive substances) and the induction of several pathologies in an acute setting (i.e. trauma, myocardial infarction, stroke) or a long-lasting situation (i.e. diabetes, high blood lipids, high blood pressure, excess of unhealthy food).
The loss of the equilibrium between the production of oxidative stress and its removal (“loss of redox homeostasis”) is also characteristic of aging and degenerative processes (i.e. joints, neurons).
Find out more about LarmorBio's unique and proven approach to quantifying oxidative stress from blood in real-time
Proprietary Microscale NMR
Proprietary Data Analytics
Recent Publications and some ongoing clinical studies
Responsive biomarker to drug interventions
GLP-1 Analogues
Metabolic healthy vs unhealthy with varying nutritional loas
Ferroptosis: Iron-induced cellular death
"The LarmorBio platform helped us quantify intracellular ferric Ion (Fe3+) and ferrous ion (Fe2+) homeostasis in h9c2 cardiomyoblast cells. The assay requires minimal sample preparation and is easy to use.
Truly an exciting technology that has potential diagnostic applications."
Chester Lee Drum Lab
Duke NUS
Monitoring blood oxidative levels in pregnant women receiving digital health intervention designed for improved metabolic health
Advanced, real-time,individualized cardiometabolic insights
Cellular oxidative stress assays developed by world-class team of medical scientists, molecular biologists, data scientists, and engineers.
Peer-reviewed in high-impact journals.
1st generation liquid biopsy platform already in use at leading medical research hospitals and pharmaceutical companies.
Interdisciplinary founding team
Jongyoon Han professor of biological engineering, computer science and electrical engineering at MIT,
Inventor of LarmorBio technology